Cyanokit is used in an emergency to treat cyanide poisoning. Hydroxocobalamin works by helping cells in the body convert cyanide to a form that can be removed from the body through urination. It is used as an antidote to cyanide poisoning. Be prepared to treat with anticonvulsants, vasopressors and alkalinizing agents in addition to standard supportive measures. Cyanokit contains hydroxocobalamin, a form of vitamin B-12. In addition to using antidotes, it is incumbent upon the provider to treat the associated abnormalities and symptoms of toxicity.
Sodium Thiosulfate: regenerates sulfur-dependant rhodanese activity this enzyme converts CN to thiocyanate, which is renally excreted recommended co-administration with hydroxocobalamin or nitrites, especially in prolonged exposures Sodium Nitrite: slower onset, longer lasting nitrite, as above frees up cytochrome oxidase to resume aerobic metabolism Hydroxocobalamin: combines with cyanide, forming cyanocobalamin (vitamin B12), which is renally excreted few side effects, well-tolerated by critically illĪmyl nitrite: inhaled formulation, rapidly enters circulation generating methemoglobin which has higher affinity for CN than cytochrome oxidase 100% O 2 via facemask, or ETT if intubation is indicated, though theoretically useless has potentially been helpful in some cases. Monitoring must be initiated, as well as good IV access and fluid administration begun to aid in resuscitation. Patients who present with possible exposure (including iatrogenic exposure from the cyanogen sodium nitroprusside) who are found to have progressive or severe metabolic acidosis and elevated lactate should be treated presumptively.
Primarily, treatment is aimed at uncoupling cyanide from cytochrome oxidase, and allowing cells to return to aerobic metabolism via oxidative phosphorylation. Treatment of cyanide toxicity should be initiated as soon as it is suspected do not delay treatment while awaiting formal diagnosis by blood cyanide levels.
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